- First Preview: March 10, 2017
- Opening Night: March 31, 2017
- Closing Night: May 12, 2017
- Venue: Comerica Theatre.
Original Phoenix Cast
Principals (in order of appearance)
- Heidi Blickenstaff as Miss Frizzle
- Bailey Ryon as Liz
- Corey Cott as Arnold
- Robin De Jesus as Carlos
- Nadia Vynnytsky as Dorothy Ann
- Ariana DeBose as Keesha
- Laurie Veldheer as Phoebe
- Eugene Barry-Hill as Mr. Junkitt
- Nick Nelson as Ralphie
- Judith Light as Professor Cornelia C. Contralto ll
- Victor Hernandez as Mr. McClean
- Adam Grupper as Archibald Seedplot
- Kellen Stancil as Tim
- Rachel Potter as Wanda
- Laura Irion as Janet
- Carrie Coon as Katrina Eloise Murphy
- Courtney B. Vance as General Araneus
- Tory Ross as Gerri Poveri
Students, Parents, Frizzlettes, Dancers and Denizens of Walkerville: Kyle Adkins, William Carlos Angulo, Francesca Arostegui, Stefanie Brown, Sean Cackowski, Dara Cameron, Max Crumm, Devin DeSantos, Andrew DiConcetto, Christy Faber, Victor Hernandez, Eugene Barry-Hill, Cory Hindorff, Laura Irion, Amanda LaMotte, Adrianna Lyons, Matt Meigs, Christy Morton, Jesse Nager, Tory Ross, Laura Savage, Cassie Silva, Will Skrip, Mason Trueblood, Julia Mason.
Understudies: Understudy for Miss Frizzle - Christy Morton, Tory Ross. For Arnold - Nick Nelson, Mason Trueblood. For Carlos - Max Crumm, Will Skrip. For Dorothy Ann - Francesca Arostegui, Adrianna Lyons. For Keesha - Felicia Boswell, Laura Savage. For Phoebe - Sarah Meahl, Nadia Vynnytsky. For Ralphie - Kyle Adkins, Matt Meigs. For Professor Cornelia C. Contralto ll - Christy Morton, Tory Ross. For Archibald Seedplot - Victor Hernandez, Max Kumangai. For Tim - Cory Hindorff, Jesse Nager. For Wanda - Laura Irion, Cassie Silva. For Katrina Eloise Murphy - Stefanie Brown, Laura Irion. For General Araneus - Eugene Barry-Hill, Max Kumangai.
Swings: David Armstrong, Felicia Boswell, Max Kumangai, Sarah Meahl. Dance Captain/Swing: Alex Finke. Asst. Dance Captain/Swing: Kevin Munhall.