The Frizzle residence is a house in Walkerville, and the home to both Professor Frizzle and Liz.
The house appeared only in the original series episode "Gets Charged" when the Professor's now-former students visited.
The house itself is decked out in décor including a fountain statue of Liz and some replicas of the bus, including on the mailbox. The Bus is parked on the driveway here when it is not at school.