|First Appearance||Inside Ralphie|
|Family|| Ralphie Tennelli (son)|
Mr. Tennelli (husband)
Unnamed father or father-in-law
Brian (brother or brother-in-law)
|Voiced By||Tyne Daly|
Doctor Tennelli is very much like a normal, caring mother. She does look out for her son while raising him as a single parent and also have a busy work life of her own.She seems to be mature and is respectful towards Ms. Frizzle. She knows that Ralphie and his class go on a lot of exciting experiments, but it's not known if she knows the intensity of them, whether its going back in time, shrinking and going inside the human body, or getting eaten.